Flaviviruses are neurotropic, but how do they invade the CNS?
Flaviruses (FV) are RNA viruses carried by mosquitoes. Neurological signs including acute encephalitis, meningitis and acute flaccid paralysis develop in a small percentage of infected individuals; long term sequlae are, Parkinsonism, dystonias and cognitive changes. FV neuroinfection is neurotropic involving subcortical nuclei (substantia nigra and thalamus) anterior horn neurons and neocortex. Glycosylation of the FV E envelope protein is one determinant of neuroinvasion, increasing both axonal and trans-epithelial transportation. Neutralizing antibodies against the E and NS proteins prevents FV uptake into several cell types, including axons. CD8+ T cells are vital for clearance of WNF infected cells from the CNS, whereas TLR-3 and TLR-7 mediated anti-virus response through increased serum inflammatory cytokines to disrupt the BBB providing infected leucocytes and free virus access to the CNS (so called Trojan horse) Cellular virus attachment factors, promoting FV cell entry are widely distributed and include DC-SIGN (that detects complex carbohydrate molecules); Glycosamino glycans (GAG), Heparan sulphate(HSPG) Semaphorin 7A, Low Density Lipid receptors (LDLR); these are not FV specific virus entry receptors. The FV also crosses epithelial and endothelial barriers by disrupting Tight Junction complexes to increase BBB permeability. This review describes the multiple pathways responsible for the neuroinvasive properties of the Flaviviruses.
REFERENCE: Neal JW. Flaviviruses are neurotropic, but how do they invade the CNS? J Infect. 2014 Sep;69(3):203-15. doi: 10.1016/j.jinf.2014.05.010. Epub 2014 May 29. Review.
Los alumnos de maestría que ingresen a una maestría del Programa Nacional de Posgrado de Calidad (PNPC, como la UAM, IPN o UNAM), recibirán beca de Conacyt. En el Departamento de Investigación en Enfermedades Infecciosas, busca estudiantes en las áreas de laboratorio (química, biología, farmacobiología, etc.) que deseen realizar su servicio social o tesis de licenciatura o maestría en investigación básica en NEUROVIROLOGÍA. Limitado a 1 estudiante por año, de lincenciatura o maestría.
A partir del 2013, podrán participar en cualquiera de las siguientes líneas de investigación: Tratamiento in vitro de oligodendrocitos con agentes con potencial remyelinizante.Efectos virales en mecanismos de myelinización.Tratamiento de agentes remyelinizantes in vivo en modelo EAE.Patogénesis de virus Zika en sistema nervioso central.Los estudiantes interesados deberán seguir los siguientes pasos en orden: Conocimientos mínimos de inglés intermedio (la mayor parte de la información se manejará …
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